Lal Research Group

Variant to Brain

Epilepsy ClinVar
Phenotype Explorer New

Epilepsy ClinVar

An interactive browser to explore ClinVar submissions for epilepsy genes through the standardized Mondo phenotype ontology.
NDD Portal
Phenotype Explorer New

NDD Portal

Explore genotype-phenotype association across neurodevelopmental disorder associated genes and Copy Number Variants (CNVs).
SCN1A-Epilepsy Prediction Model
Phenotype Explorer

SCN1A-Epilepsy Prediction Model

Calculates the probability of developing Dravet syndrome versus genetic epilepsy with febrile seizures plus (GEFS+).

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CACNA1A Portal
Gene-Specific Portal

CACNA1A Portal

For families, clinicians, and researchers dedicated to comprehending CACNA1A-related disorders.
GRIN Portal
Gene-Specific Portal

GRIN Portal

For families, clinicians, and researchers dedicated to comprehending GRIN-related disorders.
SATB2 Portal
Gene-Specific Portal

SATB2 Portal

Interactive resources for SATB2-Associated Syndrome (SAS) for families, clinicians and researchers.

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SCN Portal
Gene-Specific Portal

SCN Portal

For families, clinicians, and researchers dedicated to comprehending SCN-related disorders.
SLC6A1 Portal
Gene-Specific Portal

SLC6A1 Portal

For families, clinicians, and researchers dedicated to comprehending SLC6A1-related disorders.

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CNV ClinViewer
Variant Classification

CNV ClinViewer

Interactive visualization, genomic exploration and standardized clinical significance interpretation of large copy-number variants.

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ES-NDD Browser
Variant Classification

ES-NDD Browser

An interactive tool to explore Essential3D sites across 242 neurodevelopmental disorder associated-proteins.

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NDD CNV Viewer
Variant Classification

NDD CNV Viewer

Displays expert-curated datasets from chromosome 8p, ring 14 and dup15q CNVs with biomedical annotations, analytics, and educational resources.
Per Viewer
Variant Classification

Per Viewer

Explore pathogenic missense variant enriched regions (PERs) across genes and gene families.

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SCN Viewer
Variant Classification

SCN Viewer

Explore genetic variant effects across sodium channelopathies predict function and guide precision therapy.

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Simple Clinvar
Variant Classification

Simple Clinvar

Explore and retrieve gene and disease variants aggregated in the ClinVar database.

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How to use the gene portals

All of our gene-specific portals operate similarly, such as in this example, demonstrating how to interpret a genetic variant.




About

Description
Dennis Lal, Ph.D.

The Lal Research Group is a multi-disciplinary team focused on advancing our understanding of epilepsy and related neurodevelopmental disorders. With a diverse range of expertise, the group investigates various aspects of these conditions using a combination of technological, computational, and data-driven approaches. Learn more

Dr. Dennis Lal is an accomplished researcher and educator in genetics and clinical neurogenetics, devoted to enhancing our comprehension of brain disorders through genomic research and its application in clinical care. As the Director of the Center for Neurogenetics at UTHealth Houston, he is continuing his ongoing research program and, clinically, is facilitating the utilization of genetic tests and advanced genetic test interpretation at the neurological institute to establish gene-informed precision medicine clinical trials. Learn more



Clinic


We offer appointments at our Multidisciplinary Centers for CACNA1A-related and SCN2A-related disorders, as well as tele-health genetic counseling appointments to help patients and their families understand their genetic diagnosis and genetic testing results.


SCN2A Clinic

Multidisciplinary Center for SCN2A Disorders
UT Physicians
Welcome to the first-ever SCN2A Multidisciplinary Center, designated by FamilieSCN2A Foundation. We’re dedicated to delivering top-quality care and pioneering research for adults and children affected by SCN2A-related disorders. Learn more

CACNA1A Clinic

Multidisciplinary Center for CACNA1A Disorders
UT Physicians
Welcome to the Multidisciplinary Center for CACNA1A-Related Disorders at UTHealth Houston, a premier facility that provides comprehensive care and innovative research for individuals affected by CACNA1A-related neurological and developmental disorders. Learn more

Telehealth Clinic

Telehealth Genetic Counseling for Epilepsy
UT Physicians
UTHealth Houston offers virtual genetic counseling appointments to help patients and their families understand their genetic diagnosis and genetic testing results. Our program provides genetic counseling consultations for children and adults with genetic epilepsies and/or neurodevelopmental disorders. Learn more